标签： 上海花千坊会所

Nine-valent HPV vaccine is ＂one vaccine is hard to find＂. Can relaxing the age limit alleviate it？

　　Zhongxin Jingwei, July 12 (Lin Yusi) With the increasing demand for HPV vaccine, the demand for HPV vaccine is in short supply due to limited production capacity, especially the nine-valent vaccine "one vaccine is hard to find", which makes many women who seek seedlings miss the best vaccination age.

　　Under this circumstance, recently, in some areas, the voice of "Nine-valent vaccine is about to relax the age limit to 45 years old" appeared. So, is it realistic to "age-extend" the nine-valent vaccine? How long will it take to achieve it?

　　Photo courtesy of nine-valent vaccine packaging box respondents

　　"selling contract packages" and "distributing goods" to sell nine-valent HPV vaccines

　　Cervical cancer is mainly caused by human papillomavirus (HPV). Wu Tao, an attending physician in the Department of Gynecology and Oncology of Shaanxi Cancer Hospital, told Zhongxin Jingwei that there are more than 100 kinds of HPV viruses, which are divided into high-risk and low-risk types. The common high-risk HPV types in China include 16, 18, 31, 33, 45, 52 and 58. Women who usually have sex may be infected with HPV virus, but most of them are transient infections. Like a cold, the body’s resistance is normal, and most of them can turn the virus negative by relying on their own immunity within one year. However, a small number of people with persistent high-risk human papillomavirus infection (generally believed to be more than one year) will lead to cervical precancerous lesions, which will continue to develop and even progress to cervical cancer.

　　However, cervical cancer can also be prevented, and the incidence of cervical cancer and precancerous lesions will be significantly reduced by vaccinating HPV vaccine among school-age women.

　　According to the annual report of Wan Tai Biology in 2021, according to the data of vaccine signing and wholesale by the Central Inspection Institute and local inspection institutes, from the perspective of large varieties, 181 batches of bivalent HPV vaccines were signed and wholesale, up by 269% year-on-year, and 44 batches of nine-valent HPV vaccines were issued, up by 83% year-on-year.

　　Even so, the nine-valent HPV vaccine is still "one seedling is hard to find" and even more sales tricks appear.

　　Recently, according to media reports, HPV vaccine needs to be "distributed", that is, with other vaccines or physical examinations, in order to get an HPV vaccine. A scalper who can help make an appointment for a nine-valent HPV vaccine told Zhongxin Jingwei that some hospitals have the situation of "selling contract packages", that is, compulsory physical examination, charging extra fees and bringing some profits to hospitals.

　　In addition, the scalper also revealed that because there are too many people who need to be vaccinated, releasing seedlings will never satisfy the market. In addition to releasing seedlings, some hospitals will buy and sell seedlings. The scalper said that he can help to make an appointment for the nine-valent seedlings by paying another 2,000 yuan, and he can make an appointment in about two weeks at the earliest. "All three needles can be made, and there is no need to renew the appointment. The needles are really nine-valent seedlings, and the traceability code on the box can be scanned to check the authenticity."

　　Nine-valent vaccination card in the new Jingwei Lin Yusi photo

　　Faced with the situation that the domestic HPV vaccine market is in short supply, there are also criminals who profit from smuggling nine-valent HPV vaccines at low prices. Recently, Liuzhou Intermediate People’s Court of Guangxi issued a first-instance verdict on a case of smuggling nine-valent cervical cancer vaccine. The defendant Xu Moli and other four people bought vaccines from Hong Kong at a low price and smuggled them to Shenzhen, and then sold them to various places. Four people smuggled 2,824 vaccines, involving nearly 3 million yuan, with a total profit of more than 120,000 yuan.

　　In fact, it is really helpless for people to turn to the yellow cattle to make an appointment and be asked by the hospital to "distribute" the seedlings. The way to make an appointment for HPV vaccines in various places is harsh, and it has been a long time since they were unable to "go ashore" for many years. Zhongxin Jingwei learned that Beijing made an appointment online and by telephone. However, many community hospitals have told Zhongxin Jingwei that the nine-valent HPV vaccine has no seedlings, and I don’t know when it will be available. Some hospitals in Beijing also have household registration restrictions, and people outside the jurisdiction are not allowed to vaccinate.

　　There are also areas such as Shenzhen that decide who can be vaccinated by "shaking the number". Many people have reported to Zhongxin Jingwei that the process of shaking the number is time-consuming and labor-intensive, and the speed of fighting hands is also luck. Many people can’t get it for half a year. Even if they can get it, there is no guarantee that the other two needles can be vaccinated on time, and there may be problems of overage.

　　Why is the nine-valent HPV vaccine still "one vaccine is hard to find"?

　　It is understood that there are currently three kinds of HPV vaccines listed in the world, and the number of HPV virus subtypes is different, including bivalent vaccine, tetravalent vaccine and nonavalent vaccine. Five HPV vaccine products have been approved for marketing in China, including three imported HPV vaccines and two domestic HPV vaccines.

　　In 2006, the world’s first HPV vaccine came out, until 2016, the first HPV vaccine approved for marketing in China — — The bivalent HPV vaccine "sirrah Shi" produced by GlaxoSmithKline has been in a blank period in China for ten years.

　　Luo Ling, the fund manager of Shanghai Congrong Investment Management Co., Ltd., said in an interview with Zhongxin Jingwei that the reason for the current strong demand is that many people have not been vaccinated with HPV before, and the demand has accumulated to be released at this stage. The next 5 to 10 years may be the stage of replanting the stock population, followed by the annual vaccination of the new population.

　　In 2018, the U.S. Merck nine-valent HPV vaccine "Jiadaxiu" was listed in mainland China, and Zhifei Bio became the exclusive agent of Merck HPV vaccine in China. However, up to now, the nine-valent HPV vaccine is still hard to find.

　　Behind the lack of seedlings, there is only one nine-valent vaccine manufacturer in Merck. Recently, Tian Anna, president of Merck China, pointed out in an interview with the media that it takes nearly four years for each dose of HPV vaccine to be produced and applied.

　　However, the supply of nine-valent HPV vaccine has also increased accordingly. Recently, Zhifei Bio said on the interactive platform that in the first quarter of 2022, the number of batches of nine-valent HPV vaccines increased by nearly 280% year-on-year.

　　Wu Tao said that vaccination with HPV vaccine is the best way to prevent HPV infection and cervical cancer, but don’t blindly wait and pursue the most expensive vaccine, but should be protected as soon as possible. If there is no nine-valent HPV vaccine, it is a better choice to vaccinate low-priced HPV vaccine.

　　In addition to the nine-valent HPV vaccine, the four-valent HPV vaccine market is currently in the hands of Merck. It is understood that the whole vaccination cost of tetravalent and nine-valent vaccines is 2394 yuan and 3894 yuan respectively. In the market competition of bivalent vaccine, domestic vaccine also gets a share with its price advantage.

　　In 2020, Wan Tai Bio’s bivalent HPV vaccine "Xinkening" went on the market, and one shot was only 329 yuan. Even if it was inoculated with three shots, it was only 987 yuan, far lower than the 1,740 yuan of the same dose of GlaxoSmithKline "sirrah Shi".

　　As the first domestic HPV vaccine, "Xinkening" adopts the research and development route of Escherichia coli technology, with low cost and high efficiency. According to the 2021 annual report, the biological business income of Wan Tai increased by 144.25%, mainly due to the increase of bivalent HPV vaccine, reagents and active raw materials, and the gross profit margin of vaccine business was as high as 92.55%. In 2021, the sales of bivalent HPV vaccine in Wan Tai exceeded 10 million, and the government procurement accounted for only 1.5%.

　　In March, 2022, watson biological bivalent HPV vaccine "Wozehui" was also approved for listing, and it was officially put on the market at the end of May, taking away part of the biological market in Wan Tai at a lower price.

　　At the end of May this year, the bivalent HPV vaccine of watson biological and Wanbiotai jointly won the bid for the procurement project of Jiangsu provincial government. The total purchase quantity is 32,000 pieces, of which 22,400 pieces were won at the proposed bid price of 246 yuan/piece in watson biological and 329 yuan/piece in Wan Tai Bio, only 9,600 pieces were won.

　　In this regard, Wan Tai Bio said that since its listing, its bivalent HPV vaccine has been mainly supplied to the self-funded market, and the purchase of free voluntary vaccination by local governments for specific age groups is relatively small, which has limited impact on the company’s operating income.

　　However, Wu Tao told Zhongxin Jingwei that there are regional differences in the distribution of cervical cancer in China, mainly concentrated in the central and western regions, and rural areas are highly prevalent in cities. Clinically, patients with advanced cervical cancer are mostly from rural areas. There are hundreds of millions of low-and middle-income women in China, who are concerned about the price of HPV vaccine besides the preventive effect and safety. "For economically underdeveloped people, the price will directly affect the choice of HPV vaccine types."

　　Is it close to relaxing the age limit?

　　On the track of nine-valent HPV vaccine, which is in short supply, there are more and more R&D and production enterprises in China. It is worth noting that some domestic nine-valent vaccines are expanding the age of the experimental population compared with the suitable age of 16 to 26 years approved by Merck nine-valent vaccine in Chinese mainland.

　　This may mean that with the listing of more nine-valent HPV vaccines in the future, not only can the situation of "one vaccine is hard to find" be alleviated, but the waiting school-age women do not have to be anxious because they are over 26 years old.

　　It is understood that Chongqing Bowei Baitai Biopharmaceutical Co., Ltd. (hereinafter referred to as Bowei Bio), Jiangsu Ruike Biotechnology Co., Ltd. (hereinafter referred to as Ruike Bio), Beijing Kangle Guardian Biotechnology Co., Ltd. and Wan Tai Bio’s nine-valent HPV vaccine have all entered the third clinical stage.

　　Wan Tai Bio started the Phase III clinical trial in September 2020. At that time, the company said that the phase III clinical trial of the nine-valent vaccine was aimed at evaluating the effectiveness and safety of the vaccine in female healthy volunteers aged 18-45. However, as early as 2020, Wan Tai Bio said that the nine-valent vaccine is not expected to be listed within three years according to clinical experience.

　　According to the information of National Medical Products Administration Drug Evaluation Center, the phase III clinical trial of nine-valent vaccine announced by Bowei Bio in 2020 also aims to evaluate the immunogenicity and safety of HPV vaccine among women aged 20-45 in China. Phase III clinical trial was completed in September 2021.

　　In June, 2021, Ruike Bio announced the effectiveness and safety of its nine-valent vaccine in the phase III clinical trial of healthy women, one of the purposes of which was to evaluate the safety and immunogenicity of three doses inoculated in healthy women aged 9-17, 16-26 and 18-45. However, the company did not disclose the completion date of the test.

　　Tao Lina, a vaccine expert, said in an interview with Zhongxin Jingwei that the duration of the third phase clinical trial needs to refer to the sample size: the larger the sample size and the higher the cost, the shorter the observation time; The smaller the sample size, the longer the observation time. You can’t have both fish and bear’s paw, with a large sample size and high investment. It will take one or two years to observe the third-phase clinical trial before you can see the significant difference between the vaccine group and the placebo group. The sample size is small, and it may take more than five or six years to get the difference of incidence and summarize it. It will take at least 2 to 6 years from the start of the third phase clinical trial of domestic HPV vaccine to the approval and listing.

　　Wu Tao told Zhongxin Jingwei that in 2019, Merck launched the third phase clinical trial of nine-valent HPV vaccine in China, bridging the immunogenicity and immune persistence test. The observation period is five years, that is, the earliest nine-valent HPV vaccine in China may relax the age limit to 45-year-old women by 2024. Men’s enrollment is also under way. However, if men in China want to get the nine-valent vaccine, they have to wait five years at the earliest.

　　However, Taulina also pointed out that relaxing to the age of 45 also means that more people are snapping up the nine-valent vaccine, which is still difficult to alleviate the situation of "one needle is hard to find" and even more intense. (Zhongxin Jingwei APP)

　　(The opinions in this article are for reference only, and do not constitute investment advice. Investment is risky, so you should be cautious when entering the market. )

Nanjing police cracked the case of spreading obscene articles on the Internet, and most of the suspects were highly educated.

　　After the suspect is arrested, the on-site evidence is fixed.

　　Recently, the Jiangbei New District Branch of Nanjing Public Security Bureau successfully cracked a case of selling and spreading obscene articles for profit in the action of Net Net 2019, cut off an industrial black chain involving shooting, selling and spreading obscene photos and videos for illegal profit, and arrested 20 suspects, involving more than 4 million yuan. Surprisingly, most of the suspects arrested by the police have high education and high income, but in order to stimulate or seek high income, they ignore the law and go to the road of no return.

　　Yangzi Evening News/Yangyan reporter Mei Jianming

　　Correspondent Jiang Jingxuan

　　An alarm call brought out thousands of member porn websites.

　　"110? I want to call the police. There is a pornographic website with many obscene photos and videos. " At the beginning of April this year, Nanjing Jiangbei New District Public Security Bureau received an alarm call from Mr. Zhang, a resident of the jurisdiction. Mr. Zhang told the police that he accidentally discovered that his son had logged into a website, and someone on it actually sold a set of obscene photos and videos at a clear price. "These photos and videos, the pictures are gaudy and vulgar, and they are basically obscene and pornographic, which is unsightly. This kind of thing will definitely have an impact on children on the Internet!" Mr Zhang said angrily.

　　After receiving the alarm, the police immediately started the verification work. After investigation, it was found that the photos and videos on the website mentioned by Mr. Zhang were obscene, with more than 3,000 registered members, which had a bad social impact. "This website can only see some explicit photos before logging in. After registering and recharging 300 yuan as a member, users can see some previews of all kinds of obscene photos and videos. If you want to see more or download, you need to pay another fee." Yin Zhihui, a policeman handling the case, told reporters.

　　According to reports, the website has set up two recharge methods: ordinary members and life-long members. The prices are 300 yuan and 1000 yuan, respectively. Only when you become a member can you buy photos and videos in the website. According to the content published on the website, the police handling the case initially determined that there was an illegal act of spreading obscenity and pornography for profit, and filed a case to start detailed evidence collection.

　　There are millions of obscene photos hidden in small websites, and registered photographers are spread all over many provinces.

　　The police investigation revealed that on the one hand, the website was contributed by registered photographers and uploaded their own obscene photos and videos in the original area; On the other hand, we set permissions on these photos and videos, and make huge profits by attracting registered members of netizens to buy them. Pictures and videos are graded according to the model’s "quality" and exposure degree, and members are charged. 60% of the illegal income is paid to the photographer as a reward, and 40% belongs to the stationmaster.

　　"This kind of case is different from other cases of financial infringement. Because it is not limited by geography and has the characteristics of a wide area, the social communication is more serious and the impact is very bad. " The police handling the case said. By the time of the incident, all photographers on the website platform had uploaded more than 300,000 pictures and video files, attracting more than 3,000 registered Vip members.

　　After fixing the online evidence, the police began to trace the identity of the suspect. Since all the suspects are fictitious identities, it is very difficult to verify their true identities. Moreover, the website server is located outside the country and has complicated encryption programs. With the cooperation of the network security department, the police quickly identified the identity of Zhang, the stationmaster of the website. After careful investigation, the identities of more than ten photographers all over the country were also determined one by one. At this point, a criminal gang involved in the illegal dissemination of obscene articles in 7 provinces and 9 cities across the country surfaced.

　　The police closed the net at the same time in 7 provinces and 9 cities, and arrested 20 suspects in one fell swoop.

　　After finding out the criminal facts of the gang and the situation of the people involved, Nanjing Jiangbei New District Public Security Bureau and Nanjing Public Security Bureau Netan Detachment immediately held a case deployment promotion meeting, organized more than 100 police officers to form a project force, and the soldiers were divided into seven roads to go to Guangzhou, Sichuan, Hunan, Beijing, Shandong, Jiangsu and other seven provinces and nine cities to make arrests.

　　After arriving at the destination, the police of the task force immediately carried out investigations regardless of the fatigue of long-distance raids. Because we are fighting in different places, we are unfamiliar with each other, and the investigation work is very difficult. After four days of investigation, the police of the task force finally figured out the residence and work schedule of all suspects, overcoming the unfavorable factors such as unclear situation and physical fatigue in continuous operations.

　　Subsequently, the task force decided to carry out a unified arrest operation. After more than ten hours of continuous waiting, the stationmaster Zhang was first captured at home. After on-site inquiry and fixed evidence, Zhang confessed to his illegal and criminal facts. After Zhang was arrested, the arresting forces in other provinces closed the net at the same time. In this unified arrest operation, 20 suspects were arrested and more than 10 computers were seized, and finally the criminal gang suspected of illegally spreading obscene articles for profit was completely destroyed.

　　There are many suspects with high salaries and high academic qualifications, and some even quit their jobs to specialize in this line.

　　After the trial, according to Zhang, one of the suspects, he created a personal website to share his photographic works in 2012 because of his hobby of photography, but the website has not been as popular as he expected. In order to attract popularity, Zhang renamed the website in 2014, and collected some exposed pictures from the Internet and posted them on his website, and the click-through rate really increased. At the beginning of 2016, a netizen contacted Zhang actively, saying that he could provide pornographic pictures for Zhang’s website for a fee. It was this cooperation that made Zhang find a "financial road", so he simply quit his job, rented an overseas server and started a website full-time.

　　After more than two years of operation, the website has attracted dozens of photographers. Most of these photographers have received higher education from universities, and the highest degree is postgraduate. Not only that, many of them have stable and well-paid jobs. Because of the considerable and rapid benefits brought by shooting and publishing obscene pictures and videos, these people have joined in one after another and become full-time or part-time photographers of the website. The suspect Niu originally had an enviable high-paying job in Shanghai. At the beginning of 2017, Niu accidentally visited the website. Because he knew P pictures, he joined the website and became a part-time photographer under the temptation of interests. In just two years, Niu contributed more than 20,000 pieces to the website, making an illegal profit of more than 700,000 yuan.

　　The reporter learned that most of these suspects are young people in their early twenties. Because of their weak legal awareness, they embarked on the road of illegal crimes, but they never thought that they had damaged the physical and mental health of more peers. At present, the case is still under further investigation and deep excavation.

Israel will provide about $155 million in loans to Palestine.

　　Israeli Defense Minister Ganz said on August 30th that Israel will provide 500 million new shekels (about 155 million US dollars) in loans to Palestine.

　　On the 30th, Ganz revealed to the Israeli media that during his talks with Palestinian President Yasser Abbas on the 29th, he promised that Israel would take a series of "goodwill gestures", including providing loans to the Palestinians and approving 16,000 Palestinians to work in Israel.

　　Ganz said that the purpose of his talks with Abbas was to build mutual trust in the absence of a peace agreement between the two sides.

　　According to a statement issued by the Israeli Defense Minister’s Office in the early hours of the 30th, Ganz and Abbas held two rounds of talks in Ramallah, during which the two sides discussed the "security, social and economic situation" in the West Bank and the Gaza. The statement quoted Ganz as saying that "Israel is prepared to take a series of measures to promote the Palestinian economy".

　　In July this year, the Israeli security cabinet decided to freeze the transfer of 597 million new shekels (about 183 million US dollars) to Palestine to collect taxes. This "punishment" measure used by Israel has caused the Palestinian side to fall into financial difficulties.　　

　　After Abbas met with Israeli Prime Minister Benjamin Netanyahu in the United States in 2010, the leaders of the two sides never met directly again. In 2014, the peace talks between Israel and the Palestinian National Authority broke down and have not resumed.

Dalian Maybach S-class price reduction information! The highest discount 105,000, the discount waits for no one

Welcome to the Autohome Dalian Promotion Channel to bring you the latest car market trends. Currently, the high-profile luxury sedan is running a remarkable promotion, aiming to bring real car purchase benefits to consumers in Dalian area. According to the latest information, car buyers can enjoy a cash discount of up to 105,000 yuan, which reduces the starting price of this premium model to 1.363 million. This is a car purchase opportunity not to be missed. Friends who want to seize this price reduction bonus must click "Chatty Car Price" in the quotation form to get a higher discount. Take action now and experience the luxury and respect of Maybach S-Class!

大连迈巴赫S级降价信息！最高优惠10.5万，优惠不等人

The Maybach S-Class is the pinnacle of the luxury car series, and its exterior design highlights dignity and sophistication. The front face design is very recognizable, with a large area of chrome-plated elements decorating the grille, and every line reflects the perfect fusion of elegance and power. The air intake grille adopts a unique vertical layout and works like a work of art, which not only enhances the visual impact of the vehicle, but also highlights the identity of its luxury flagship. The overall style is exquisite and atmospheric, and every detail shows Maybach’s pursuit of luxury and comfort.

大连迈巴赫S级降价信息！最高优惠10.5万，优惠不等人

The Maybach S-Class is luxurious and elegant with its refined sideways lines. The body size is 5470mm*1921mm*1510mm and the wheelbase is up to 3396 mm, giving it a spacious interior space and elegant proportions. The front wheelbase is 1655mm and the rear wheelbase is 1683mm, ensuring the stability of the vehicle and the comfort of the driver. The tire specifications are unique, and the front and rear are equipped with 255/45 R19 wide tires, with exquisite wheel design, which not only enhances the driving performance, but also shows the dignity and dynamic feeling.

大连迈巴赫S级降价信息！最高优惠10.5万，优惠不等人

The Maybach S-Class’s interior design is sumptuous and sophisticated, with a unique style that blends elegance and technology. The steering wheel is made of exquisite leather, which not only provides a comfortable grip, but also is equipped with electric up and down + front and rear adjustment functions to ensure the best comfort for the driver. The 12.8-inch central control screen stands in the center of the cockpit, equipped with multimedia systems, navigation and phone functions, and intuitive and easy-to-use air conditioning controls, highlighting the intelligent driving experience.

In terms of seats, the Maybach S-Class is wrapped in top-of-the-line leather, and the seat cushions and backrests are carefully designed to provide front-rear, backrest, high-low adjustment, and multi-directional adjustment of leg and waist support to ensure passengers enjoy the ultimate ride comfort. The front seats are equipped with heating and ventilation functions, as well as power seat memory functions to meet the individual needs of drivers and passengers. The second row seats are also thoughtful, adjustable back and forth and equipped with leg rests to create a distinguished mobility space.

大连迈巴赫S级降价信息！最高优惠10.5万，优惠不等人

The Maybach S-Class is powered by a 3.0-liter turbocharged inline-six engine with a maximum power of 280 kilowatts. The engine produces 500 Nm of torque, which is matched by a high-efficiency 9-speed manual transmission, ensuring a smooth driving experience and outstanding performance.

Summarizing the owner’s evaluation, the Maybach S-Class’s exterior design is deeply appreciated by him. It is not only highly recognizable, but also has a unique temperament that surpasses that of the same class. He specifically mentioned the double Maybach he saw on the road, which inspired his interest in personalized modifications. For drivers who pursue a unique and luxurious experience, the Maybach S-Class is undoubtedly a luxury option worth considering.

The movie ＂Rage＂ turned on, Andy Lau Nicholas Tse appeared on the set


1905 movie network news The action crime film was officially launched on October 17, and Dr. Yang Shoucheng, chairperson of Emperor Group, attended the event in person. The film’s luxury main creative lineup was exposed for the first time, and it was produced, directed, and directed by the action director. Andy Lau and Nicholas Tse starred, starred, and were specially invited to act as cinematographers. In addition, a number of powerful actors such as Lin Qiunan and Lin Qiunan were also assembled.At the start-up scene, Andy Lau and Nicholas Tse distributed "flame red envelopes" to the crew, wishing the shooting a smooth success. During the interview session, the main creators also shared a lot about the shooting preparation, cooperation experience, and character characteristics.



Andy Lau, Nicholas Tse’s "Stranger Brothers" meet again

"Get angry" on the boot scene and play with video elements


The film "Rage" is led by two powerful actors, Andy Lau and Nicholas Tse. This is the second collaboration between the two after 12 years ago. In "New Shaolin Temple", the two played a pair of brothers who used to be brothers but betrayed each other. The characters are one good and one evil, and the tension is full. Now that they cooperate again, the relationship and competition between the two characters are still confusing, and the black and evil forces hidden behind the two people also add a touch of mystery to the whole story, making the film story more exciting. On the day of the film’s launch, many main creators were present, such as Andy Lau, Nicholas Tse, Jinsha, Xu Guanwen, Xie Miao, Lv Liangwei, Lin Qiunan, Fang Ping, Chen Jiale, Zhang Wenjie, Shen Zhenxuan, Beard Tong, Tang Junci, Tang Jialin and other actors all appeared one by one. Andy Lau and Nicholas Tse also distributed "tinder" red envelopes at the scene, which symbolizes the tinder planted when the camera starts today, and hope that the tinder will burn in the future. At the same time, they also wish the film a smooth shooting and push the atmosphere of the scene to a climax.


The film has gathered many old friends this time. Andy Lau and Nicholas Tse are deeply touched by the re-cooperation after a 12-year gap. Lau talked about his early acquaintance with Nicholas Tse, expressing that he has a feeling of watching Nicholas Tse grow up. As the film’s action director, Nicholas Tse revealed that he designed an exclusive action scene for Andy Lau, and Andy Lau joked: "Ting Feng loves me so much." The two also expressed appreciation and recognition when talking about the cooperation with young actors. This sand also revealed that he entered the group training a month in advance and liked the action scenes designed by Nicholas Tse for him. He also said that he grew up watching Hong Kong films, and this time he came to Hong Kong to film has a feeling of "dream into reality". In addition to the new generation of young actors joining, the film also invited Xie Miao to "return". Xie Miao, who returned to Hong Kong to film after 30 years, also expressed his nostalgia for Hong Kong films, and sighed: "Hong Kong films have been brilliant for so many years because they are very professional. There is a kind of inheritance of masters and apprentices, no matter how long it takes, it still tastes like that."


Brilliant lineup detonates character memory

Dig deep into the boundaries of human nature under the scene


The movie "Rage" gathers many powerful actors, many of whom have cooperated several times. The brotherhood between Andy Lau and Nicholas Tse in "New Shaolin Temple" is regrettable. The roles played by the two still seem to have a great disparity in identity. One is an honorary representative of the Hong Kong police force, and the other is a vicious criminal who committed crimes. How do the stories between them collide? Therefore, this sand, which is well known to everyone, will also change the screen image of the previous "Fairy Fluttering", subvert and challenge the tough guy characters. In order to get close to the character image, not only did he train hard in action scenes, but also further adjusted his skin color. Previously, it was also "ridiculed" by netizens. Xie Miao, who has starred in the series, once again starred as a police officer, and will also act in Hong Kong movies in 30 years. His martial arts skills will also inject fresh vision into the action scenes. In addition, the film gathers the two generations of "Ding Li", Andy Lau and Lv Liangwei, in the same frame. Whether the two will have a rival scene is expected. In addition to the strong lineup and action scenes, the film will also dig deep into the meaning and value of the story. In addition to the confrontation between justice and crime, it will also probe deeply into emotion and human nature, looking forward to bringing innovative breakthroughs in style to the crime action genre.


Stay tuned for the movie "Rage".


Takeaway’s revenue exceeded 300 billion yuan last year. Is your Internet takeaway healthy enough？

　　Eating and ordering takeout has become the lifestyle of many young people. Data show that the scale of China’s catering industry exceeded 4 trillion yuan in 2018, of which the takeout revenue exceeded 300 billion yuan, accounting for 7.5% of the national catering market. But is your takeout healthy enough? This question has left nutritionists worried. Recently, the 2019 China Nutrition Society-Yum Brands Catering Health Foundation Annual Meeting and the 12th Catering Health Academic Symposium with the theme of "Catering Innovation and Nutrition Health" was held in Hangzhou, and Internet catering health has become a hot topic of concern for experts. Chen Junshi, an academician of the Chinese Academy of Engineering, pointed out that in recent years, takeout has emerged in the catering industry, and the number of people eating out is increasing. How to make takeout more nutritious and balanced needs to innovate the health education model.

　　data

　　Hot and sour potato shreds top the takeaway list

　　According to the "Internet Catering Status Survey" conducted by Dr. Xu Weisheng of the Institute of Nutrition and Health of the Chinese Center for Disease Control, there are more than 1 billion online ordering users worldwide, of which China’s online ordering turnover accounts for 40%, ranking first in the world. Internet catering has entered a period of maturity and deepening, and the scale of takeaway transactions has maintained an annual growth rate of more than 20%. In 2018, the scale of Chinese catering exceeded 4 trillion, and takeaway exceeded 300 billion yuan. There are more than 11 million online restaurants in China, of which about 4 million are takeaway restaurants, with a penetration rate of 36.3%.

　　According to the data analytics of the Ele.me platform in 2018, although the proportion of users ordering takeaway every day or the next day is only 5%, the number of users ordering more than 200 times a year has exceeded 10 million. Takeaway orders are mainly for lunch and dinner. The national per capita customer unit price is mainly 20-39 yuan. Orders with a customer unit price of more than 100 yuan increased by 56% year-on-year in 2017.

　　Through the data mining analysis of takeaway orders, Xu Weisheng found that people’s overall meat consumption is high, aquatic product consumption is low, and there are more fried and spicy foods.

　　Interestingly, in the list of the top ten online meals ordered for lunch and dinner on the Internet, "hot and sour potato shredded" firmly occupies the first position. In addition, burgers, fried chicken fins, and shark-flavored shredded meat also make the list. "Long-term high-frequency consumption of high-oil and high-salt foods may increase health risks such as overweight, obesity, and hypertension. It is recommended that citizens should increase the amount of vegetable food when ordering takeout, and catering companies should also increase the supply of such food." Xu Weisheng advised.

　　trend

　　Internet catering health attracts attention

　　The Chinese Nutrition Society – Yum! Brands Catering Health Fund was jointly established by the Chinese Nutrition Society and Yum! Brands China to support food health and nutrition science research.

　　The reporter found that among the projects funded in 2018, the nutrition and health of eating out became a hot topic. Ma Wenjun, director of the Guangdong Provincial Institute of Public Health, reported at the meeting that he is working with Guangdong University of Technology to "Eat Out Nutrition Evaluation APP" to try to build a Cantonese food database and train artificial intelligence image recognition technology, allowing users to identify dietary nutrients and obtain nutritional guidance by taking pictures through the APP. Professor Fan Zhihong of China Agricultural University also pointed out at the meeting that the survey shows that compared with eating at home, the intake of fat and sodium is higher, which increases the risk of hypertension and obesity. It is recommended to improve the nutritional environment of catering and promote nutritional health.

　　The special project fund will give priority to two research directions this year, namely the innovative technology of the catering industry in the "three reduction" and the construction of healthy restaurants. Among the 60 project applications, the expert team reviewed and voted by the fund management committee. Finally, 7 projects including "Research on the Status of Online Food Ordering and Nutrition and Health Issues of College Students" and "Development of a mobile end evaluation system for the nutritional environment of new catering units of your choice" were funded by the fund.

　　Professor Yang Yuexin, Chairman of the Chinese Nutrition Society, Academician Chen Junshi of the Chinese Academy of Engineering, Professor Yang Xiaoguang, Vice Chairman of the Chinese Nutrition Society, Professor Su Yixiang, Honorary Director, Ms. Wang Lizhi, Chief Public Affairs Officer of Yum China, and more than 100 experts and scholars from the field of nutrition and health, representatives of relevant government departments and media representatives attended the meeting. According to the data released by the conference, as of this year, the special project fund has funded more than 70 scientific research projects, with a total funding amount of more than 18 million yuan.

　　Yan Huifang, reporter of Nanfang Daily

Ministry of Communications： Continue to remove Didi Hitch from the shelves before completing the rectification of hidden dangers

　　On November 28th, according to the WeChat official account of the Ministry of Transport, on the morning of the 28th, the Ministry of Transport held a news conference on the inspection of the special project of the online car ride-hailing type safety, in conjunction with the Central Network Information Office, the Ministry of Public Security and other departments, reported the inspection work. According to the report, Didi has 7 main problems, and continues to remove the Didi ride-hailing business before completing the rectification of potential safety hazards.

　　Check the basics

　　Since the beginning of this year, there have been cases of passengers being killed in Didi Hitch in Zhengzhou, Wenzhou and other places. The central leadership has attached great importance to it, and the social impact has been very bad.

　　After the inter-ministerial joint meeting on the coordinated supervision of new business models of transportation, the Ministry of Transport, the Central Political and Legal Committee, the Central Network Information Office, the Development and Reform Commission, the Ministry of Industry and Information Technology, the Ministry of Public Security, the Ministry of Justice, the Ministry of Emergency Management, the People’s Bank of China, the General Administration of Market Supervision and other 10 departments formed a special project inspection working group for safety. From September 5th to 15th, Didi, Shouqi, Shenzhou, Cao Cao, Yidao, Meituan, TikTok, Autonavi and other 8 major online car-hailing and ride-hailing platform companies carried out joint security project inspections and went to Zhengzhou and Wenzhou to learn about the case.

　　At the same time, all localities have also carried out safety inspections on other online car-hailing and ride-hailing platform companies in the region with reference to the form and content of ministerial-level inspections.

　　In accordance with the decision-making and deployment of the State Council, the Ministry of Transport, together with relevant departments, has always adhered to the basic principles of people-centered and "encouraging innovation and standardized development" for new forms of transportation services such as online car-hailing, and implemented inclusive and prudent supervision. The special project inspection work adheres to the problem-oriented and goal-oriented, and in accordance with the principle of "comprehensive coverage and key points", "check the pulse of the physical examination and prescribe the right medicine" for the platform company, focusing on the platform company’s existing problems affecting public safety, passenger personal safety, information and other issues. At the same time, adhere to the rectification while inspection, urge and guide the platform company to check the problem, analyze the cause, make immediate changes, block security bugs, and effectively protect the safety of people’s lives and property.

　　The main issues identified

　　From the inspection, Didi mainly has the following seven problems:

　　First, there are major security risks in Hitch products. There are risks of user personal information leakage and security risks, product "social" positioning induces major security risks, Hitch rules violate relevant national and local regulations, are suspected of illegally operating road passenger transportation, and the business fund settlement model is not compliant.

　　The second is that the main responsibility for safety production is not in place. The safety management organization is not perfect, the safety management system has major deficiencies, the safety production responsibility system and the accident hidden danger investigation and management system have not been implemented, and the safety production costs have not been fully guaranteed. Safety management personnel have not passed the assessment and have not carried out driver training and education as required.

　　Third, the problem of illegal operation of online car-hailing is prominent. There are a large number of unqualified illegal operations of platform companies, vehicles and drivers.

　　Fourth, the foundation of emergency management is weak and inefficient. The formulation of emergency plans is unscientific, the system is not perfect, the emergency drills are not in place, the emergency management personnel are seriously insufficient, the customer service personnel are seriously insufficient, the emergency response efficiency is low, and the linkage mechanism with relevant departments is not perfect.

　　Fifth, the risk of social stability is prominent. To promote the "rent-based purchasing" business, the operating rules such as order dispatch and distribution mechanism are opaque, and orders are changed day by day, which poses hidden dangers of instability.

　　Sixth, the problem of public safety hazards is relatively large. The driver’s qualification and background review are not in place, the company’s offline management of people and vehicles is out of control, criminal security cases occur from time to time, the main responsibility of comprehensive social security management is missing, the early warning and cleaning of high-risk drivers are not in place, the abnormal itinerary and abnormal order cancellation are not effectively monitored and managed, and the APP safety function settings are not perfect.

　　Seventh, there are hidden dangers in Internet information security. There are loopholes in information systems, hidden dangers and risks of being attacked by external hackers and unauthorized access by internal employees; data grading and classification management requirements are not strictly implemented, and user personal information is stored in plain text; information security responsibilities of employees in important departments and positions are not implemented effectively, and specific measures are not enough; Insufficient management and training of employees in information security.

　　For the other seven platform companies, the main issues identified during the inspection included:

　　First, the compliance rate of online car-hailing is still insufficient. Some "asset-heavy" platform companies have high compliance rates for their own vehicles, but some "asset-light" companies have low compliance rates. Second, safety production management needs to be strengthened urgently. There are problems to varying degrees in implementing the main responsibility of safety production, signing safety production responsibility letters at every level, and strengthening safety production education and training.

　　Third, there are deficiencies in public security prevention. There is a general lack of dynamic management of the background situation of vehicles and drivers, and security protection technology needs to be improved. Fourth, there are hidden risks in Internet information security. Some companies have not implemented the relevant work of grade protection as required, the data grading classification management regulations are not clear, and the management and training of internal information security of enterprises are insufficient. Fifth, some product capital settlement models are not compliant, and there are capital security risks.

　　Handling opinions on relevant responsible units and responsible personnel

　　In response to the problems discovered by the inspection team, the inspection team formed opinions on the handling of relevant responsible units and responsible persons according to law, mainly including the following aspects:

　　The first is to continue to remove Didi Hitch from the shelves before completing the rectification of potential safety hazards. For Didi, there are serious illegal acts of wantonly engaging in illegal business activities in the name of Hitch, endangering social and public interests, and major liability accidents and multiple safety production accidents have occurred, resulting in serious consequences. The company is ordered not to continue to carry out Hitch business until the rectification of potential safety hazards is completed.

　　The second is to deal with illegal operations in accordance with the law. The relevant territorial management departments shall, in accordance with the "Interim Measures for the Administration of Online Booking Taxi Business Services" and the relevant requirements of the local implementation rules, severely crack down on online car-hailing platforms and private passenger car sharing information service platforms for illegally engaging in taxi business activities, and increase penalties for platform companies and other enterprises.

　　The third is to impose administrative penalties on the relevant responsible persons in accordance with the law. The relevant territorial management departments shall impose administrative penalties such as fines on the main responsible persons and legal representatives of Didi Chuxing Technology Co., Ltd. in accordance with the relevant provisions of the "Safety Production Law". At the same time, the company is required to handle the internal responsible persons according to the list of problems.

　　The fourth is to deal with suspected acts of excluding and restricting competition and publishing illegal advertisements. For Didi’s suspected use of market dominance to obtain improper benefits, in accordance with the Antimonopoly Act and other laws and regulations, the market supervision department will take the lead in organizing interviews and issuing reminders. For Didi Hitch’s previous propaganda advertisements suspected to contain content that obstructs social public order and violates good social customs, interviews will be conducted and disposed of according to law.

　　Requirements for rectification of platform companies

　　According to the problems found in the inspection, the Joint Inspection Unit put forward rectification requirements for Didi Company. The specific requirements are as follows:

　　The first is to strengthen the safety management of hitchhiking. Offline rectification of hitchhiking hidden dangers, comprehensive self-inspection and rectification of hidden dangers, before the rectification of hidden dangers is completed, the hitchhiking business will be stopped indefinitely, and the privacy protection of users’ personal information will be strengthened. Strengthen new product security evaluation.

　　The second is to implement the main responsibility of safety production. Strictly implement the "Safety Production Law" and other laws and regulations, establish and improve the company’s safety production management rules and regulations, strengthen the construction of offline safety forces, improve the cooperation mechanism between government and enterprises, implement the safety production responsibility system, strengthen the investigation and management of hidden dangers, and strengthen Security Training education.

　　The third is to operate in full compliance with the law. In accordance with relevant regulations, comprehensively promote the compliance of online car-hailing, remove non-compliant vehicles and drivers on the platform as soon as possible, and connect the online car-hailing operation information data to the national online car-hailing supervision information exchange platform according to regulations, and ensure data quality.

　　The fourth is to improve emergency response capabilities. Improve and perfect the company’s emergency plan system, enhance the pertinence, practicality and operability of emergency plans, improve the emergency response mechanism for emergencies, and effectively achieve responsive and efficient handling. Increase customer service force allocation and handling capabilities. Strengthen customer service personnel training, strengthen complaint handling capabilities, and improve customer service personnel response capabilities. Improve the linkage mechanism with relevant management departments to ensure rapid response and handling of emergency incidents.

　　The fifth is to implement the main responsibility for social stability. Take the initiative to implement the main responsibility for social stability of enterprises, respond to drivers’ demands for enterprises in a timely manner, resolve conflicts in a timely manner, strengthen the education and management of connected drivers, and cooperate with relevant departments to maintain industry stability.

　　The sixth is to strengthen the governance of public safety issues. Take good care of the access of vehicles and drivers, strengthen the dynamic verification of vehicle and driver qualifications, strengthen the dynamic risk management and control of vehicle operation, strengthen the consistency review of online and offline people and vehicles, resolutely block "impostor" security bugs, and implement the main responsibility of comprehensive social security management.

　　The seventh is to improve the level of Internet information security management. Conduct an overall investigation of the internal information system,. Further improve the data grading classification management measures and strictly implement them to strictly prevent information leakage. Improve the company’s information security management system, clarify the information security post responsibilities of key departments and key personnel, formulate a systematic Internet Information Security Training plan, and urge employees to further enhance their awareness of information security responsibility.

　　For the other 7 platform companies, the rectification requirements put forward by the inspection team mainly include: First, comprehensive compliance with the law. Accelerate the progress of vehicle and driver license applications in accordance with relevant regulations, and realize all legal compliance of vehicles and drivers under the platform as soon as possible. Remove non-compliant vehicles and drivers, and standardize the product fund settlement model. The second is to improve the level of safety production management. Implement the main responsibility of safety production in accordance with relevant laws and regulations, strengthen customer service team building, improve customer service team awareness and handling capabilities, and conduct regular training to continuously improve the platform company and driver emergency response capabilities. The third is to improve offline management and service capabilities. Improve vehicle and driver management mechanisms, improve offline service quality, and ensure that various safety and security measures are in place. The fourth is to strengthen the governance of public safety issues. Do a good job in security risk investigation, improve the platform APP function settings and strengthen vehicle risk management and control, and deal with vehicle dynamic risk hazards in a timely manner. Fifth, improve the level of Internet information security management. Do a good job in level protection related work, and regularly carry out information security threat and risk assessment and hidden danger investigation work. Perfect data grading classification management methods, key data should be encrypted and stored to prevent the leakage of user personal information.

　　Regarding the above existing problems, handling measures and rectification requirements, the Joint Inspection Unit has sorted out the relevant list and formally provided face-to-face feedback to the relevant platform companies.

　　In the next step, the Joint Inspection Team will guide the relevant departments of the territory to follow the requirements of relevant laws and regulations and the list of issues reported by the inspection team, and urge the platform company to seriously implement the rectification and put it in place to better ensure the safety of people’s travel.

The model of the Great Wall Gun is too complicated to know how to choose. Don’t worry, let’s analyze them one by one.

The Great Wall Gun (parameter picture) has been on the market for a long time. With the constant exposure of news, various models are emerging one after another.

On the one hand, the auto show is constantly displaying new models, and on the other hand, the Great Wall is constantly improving the models that have been listed. To tell the truth, it’s a little dazzling and difficult to distinguish.

In today’s article, we will take a good look at the models of the Great Wall Gun that have been listed, and by the way, we will talk about those models that have been exposed but have not yet been listed.

Please pay attention to the date of publication, because at the speed of the Great Wall, maybe the models in inventory today are still drawings, and they may go on sale next month.

Let’s start with the models that are already on the market.

At present, official website of the Great Wall shows that there are four pickups of the Great Wall Gun series already on the market. respectively areGreat Wall Gun Pickup Truck, Great Wall Gun Commercial Pickup Truck, Great Wall Gun Off-road Pickup Truck and Great Wall Gun.

Passenger and commercial versions of the Great Wall GunIn fact, it is the earliest model listed, and there is no difference in powertrain between them. Both of them provide 2.0T diesel and gasoline engines to choose from.

From a practical point of view, I personally recommend the diesel model.Because of the large torque of diesel oil, it can have better power performance at low speed and heavy load, and it has better fuel efficiency and stronger economy.

However, limited by the policies of some cities, it is not a day or two that diesel oil is discriminated against, so users who buy it must consult the local sales policies to avoid the embarrassing situation that they cannot be licensed.

Great Wall Gun Passenger Edition and Commercial EditionThe biggest difference is the rear suspension.The passenger version is a multi-link and integral bridge structure, while the commercial version is a leaf spring biased towards load-bearing use. This difference in configuration leads to better ride comfort in the passenger version, while the commercial version has more advantages in load.

The rest of the configuration is reflected in the luxury level.For example, the passenger version of the Great Wall Gun uses electronic power steering, which can achieve L2-level driving assistance, while the commercial version of the Great Wall Gun uses hydraulic power steering, which is more durable and practical.

Generally speaking, the passenger version and the commercial version of the Great Wall Gun have completely different user positioning, and the price difference is also very obvious, and the price is completely reflected in the specific configuration, which can be said to be very kind.

Consumers must be clear about their car purchase needs when purchasing. If a lot of time is spent on commercial purposes such as pulling goods, there is no doubt that the commercial version of the Great Wall Gun will be more suitable. And if you are an outdoor enthusiast or a pickup truck enthusiast, there is not much demand for pulling goods in actual use, then the passenger version is undoubtedly more in line with the family car.

Speaking of outdoor use, thatOff-road version of the Great Wall gun and artilleryNaturally, it is necessary to mention a few words.

In fact, pickup trucks have been used for off-road for a long time, and the Great Wall has also figured out what users want, and the products launched directly hit the core imagination of users.

existOriginal factory modificationThe cross-country version of the Great Wall Gun and the gun almost give everything in place, such as wading throats, such as winches and so on.

The advantage of original factory modification is thatThe convenience of examining carsThere is no need to remove the modified parts during the annual review, which saves the troubles of users. However, there is also a disadvantage that it is not harmful. Some users pursue the ultimate and may "dislike" the original modification of the Great Wall, which is not hard-core punk, but it is a waste if they buy it home and tear it down.

It’s normal for people to disagree, but the modification of the Great Wall has been able to meet at least 80% of users, which is also a very fortunate thing.

For the off-road version of the Great Wall Gun and artillery, I am not qualified to evaluate how to choose the two, because they are too extreme for me, and my personal car environment hardly needs such a strong off-road capability, while the home version of the ordinary Great Wall Gun can even meet my needs.

Therefore, my opinions on these two cars are for reference only.

The first is the difference between models.Because of the shorter wheelbase, the gun will have better passing ability when passing through some extreme road conditions, and the risk of bottoming will be much smaller than that of off-road guns. And a lighter body means better handling performance, which will be more dominant in high-speed crossing road conditions.

However, the absence of the second row of seats is a natural defect of artillery, which means that some valuables may not be properly stored in the car. existEmergency useIf you need to take more than two passengers one day, the artillery will also be stretched.

However, this ultimate model must also satisfy some ultimate users at the beginning of design.

Compared with artillery,Cross-country guns are more civilized and more suitable for users who like outdoor sports., can take into account domestic, commercial and off-road needs.

Therefore, how to choose depends on the purpose of their respective buyers.

I also saw many Great Wall guns in the street, and the most common ones in the urban area are the home version and cross-country guns, among which the number of home versions should far exceed that of wild guns. On the mountain roads, there will be more commercial guns, because that is the real dry goods scene.

After talking about the series of Great Wall cannons that have been listed, let’s briefly talk about those products that have not yet been listed.

Personally, I am most looking forward to the model.Travel version of the Great Wall Gun, also known as the brigade gun.

To put it bluntly, this car meets almost all my needs.

For me, I need to drive out on weekdays, and the height of the RV will limit the traffic in the city. At the same time, I also want this car to be able to load things, have at least the most basic ability to take bad roads off-road, and preferably have diesel power to choose from. What’s more, this car had better meet my camping needs. It can also get a passenger car license plate.

Almost all of the above points are met by brigade-mounted guns.Only the license plate issue has not yet landed, so we need to wait and see..

Personally, I am looking forward to this car very much. If it goes on the market, I may have a great chance to start one myself.

Another model that deserves great attention isBlack bullet of the Great Wall Gun.

As a work brought by Yun Liang’s modification and the Great Wall, I personally look forward to its performance.

As the saying goes, a good meal is not afraid of being late. I really hope that Yunliang and the Great Wall can sharpen this sword and make the products more perfect before they are put on the market. In this way, the probability of "an instant hit" will be greater, and the user’s reputation will be better.

The above is the inventory of the models of the Great Wall gun nowadays. At the speed of the Great Wall, maybe they will produce new products just after I finish writing my manuscript.

* Some pictures are from the Internet. If there is any infringement, please contact to delete them.